Description

2-Hydroxy-Dl-Tryptophan is a chiral, hydroxylated derivative of the essential amino acid tryptophan, featuring a phenolic hydroxyl group at the 2-position of the indole ring. It serves as a specialized biochemical intermediate with high value in pharmaceutical research, particularly for developing serotonin pathway modulators and novel neuroactive compounds. This compound is critically required by R&D laboratories, contract development and manufacturing organizations (CDMOs), and innovator biotech firms engaged in CNS drug discovery, peptide synthesis, and metabolic probe development.

Application

• Pharmaceutical R&D for serotonin receptor ligands and neuropharmacological tool compounds
• Chiral building block in the synthesis of modified peptides and peptidomimetics
• Metabolic tracer in stable-isotope-labeled studies of tryptophan metabolism pathways
• Reference standard for HPLC and LC-MS/MS method development and validation
• Intermediate in the preparation of photoactivatable or fluorogenic tryptophan analogues
• Substrate for enzymatic studies involving tryptophan hydroxylase and aromatic amino acid decarboxylase
• Key component in custom synthesis of GPCR-targeted probe molecules
• Research-grade material for structure–activity relationship (SAR) profiling in CNS drug candidates

Basic Information

Product Name	2-Hydroxy-DL-Tryptophan
CAS No.	21704-80-3
Molecular Formula	C11H12N2O3
Molecular Weight	220.23 g/mol
Synonyms	2-Hydroxytryptophan; DL-2-Hydroxytryptophan; 2-Hydroxy-DL-tryptophan; 2-HO-Trp; 2-Hydroxy-L-tryptophan / 2-Hydroxy-D-tryptophan (racemate); 2-(1H-Indol-3-yl)-2-hydroxypropanoic acid; β-(2-Hydroxyindol-3-yl)-DL-alanine; NSC 152963
EINECS	244-540-1

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to stringent purity and identity requirements suitable for research and development applications. Testing includes full spectroscopic verification (IR, NMR), chiral purity assessment, heavy metals screening (<5 ppm), residual solvent analysis (per ICH Q3C), and microbiological limits where applicable. Specifications meet or exceed ACS Reagent Grade and European Pharmacopoeia general monograph requirements for amino acid derivatives.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant during handling and reseal promptly after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Specific Rotation	[α]D25 = −1.5° to +1.5° (c = 1 in 0.1N HCl)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.