Description

n-Carbobenzoxy-Dl-Norvaline is a protected amino acid derivative widely used as a key chiral building block in organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates for the development of pharmaceuticals and bioactive peptides. It is particularly valuable for the synthesis of complex molecules in medicinal chemistry and proteomics research.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the norvaline residue with a carbobenzoxy (Cbz) protecting group.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the creation of compound libraries.
• Bioconjugation: Employed in the preparation of modified peptides and protein conjugates for biochemical studies.
• Chiral Auxiliary: Utilized in asymmetric synthesis due to its defined stereochemistry, facilitating the creation of enantiomerically pure compounds.
• Academic & Industrial R&D: A standard reagent in research laboratories for exploring new synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	n-Carbobenzoxy-Dl-Norvaline
CAS No.	21691-43-0
Molecular Formula	C₁₃H₁₇NO₄
Molecular Weight	251.28 g/mol
Synonyms	N-Cbz-DL-norvaline; Cbz-DL-Nva-OH; N-Carbobenzyloxy-DL-norvaline; Benzyl N-(DL-1-carboxybutyl)carbamate; DL-2-[(Benzyloxycarbonyl)amino]pentanoic acid; Z-DL-Norvaline; (RS)-2-[(Benzyloxycarbonyl)amino]pentanoic acid; NSC 3348
EINECS	Contact for details

Quality Control

Our n-Carbobenzoxy-Dl-Norvaline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, and is supplied with a corresponding Certificate of Analysis (COA). We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring compliance with global regulatory expectations for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	DL-mixture (approx. 1:1 ratio)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.