Description

H-Leu-D-Phe-Oh is a synthetic dipeptide derivative, specifically the methyl ester of the L-Leucyl-D-Phenylalanine dipeptide. This compound is a valuable chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing peptide-based therapeutics and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and for investigating peptide structure-activity relationships (SAR).
• Peptide Synthesis: Serves as a protected dipeptide building block in solid-phase and solution-phase peptide synthesis (SPPS).
• Proteomics & Diagnostics: Can be employed in the development of diagnostic reagents and probes for studying protein interactions.
• Fine Chemical Synthesis: Acts as a precursor for the synthesis of more complex, non-natural amino acid derivatives and specialized chiral compounds.

Basic Information

Product Name	H-Leu-D-Phe-Oh
CAS No.	21675-59-2
Molecular Formula	C₁₆H₂₄N₂O₃
Molecular Weight	292.38 g/mol
Synonyms	L-Leucyl-D-phenylalanine methyl ester; H-Leu-D-Phe-OMe; Methyl L-leucyl-D-phenylalaninate; Leu-D-Phe-OMe; D-Phenylalanyl-L-leucine methyl ester; (2R)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoic acid methyl ester; N-(L-Leucyl)-D-phenylalanine methyl ester
EINECS	Contact for details

Quality Control

Our H-Leu-D-Phe-Oh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-configuration for Phe)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.