Description

Proline, 4-Amino-, cis- (9Ci) is a specialized, non-proteinogenic amino acid derivative featuring a cis-configuration of its amino group relative to the proline ring. This compound matters as a high-value chiral building block and intermediate for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, peptide mimetic development, and the production of advanced fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and receptor antagonists.
• Peptidomimetics Research: Used to construct constrained peptide analogs and foldamers to study protein-protein interactions and improve metabolic stability.
• Asymmetric Catalysis: Acts as a precursor for chiral ligands and organocatalysts used in enantioselective synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to probe the function of amino acid metabolizing enzymes.
• Fine Chemical Synthesis: Utilized in the multi-step production of specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemistry.

Basic Information

Product Name	Proline, 4-Amino-, cis- (9Ci)
CAS No.	21618-64-4
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	cis-4-Aminoproline; (2S,4S)-4-Aminopyrrolidine-2-carboxylic acid; L-cis-4-Aminoproline; 4-Amino-L-proline (cis); 4-Aminoproline; (4S)-4-Aminoproline; 4-Azaproline; 4-Amino-D-proline (cis) is also a known stereoisomer.
EINECS	Contact for details

Quality Control

Our Proline, 4-Amino-, cis- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (IR, NMR) to ensure identity and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.