Description

2-Methyl-Dl-Tryptophan is a synthetic, racemic derivative of the essential amino acid tryptophan, featuring a methyl group at the 2-position of the indole ring. This structural modification makes it a valuable non-natural amino acid and a versatile chiral building block for advanced chemical synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel bioactive compounds, including peptide-based therapeutics and enzyme inhibitors. The compound serves as a critical intermediate for probing biochemical pathways and creating molecules with tailored biological activities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in oncology and neurology.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified tryptophan residues, altering peptide stability and receptor binding properties.
• Biochemical Research: Serves as a substrate analog in enzymatic studies to investigate the mechanism and inhibition of tryptophan-metabolizing enzymes.
• Asymmetric Synthesis: Employed as a starting material or resolving agent in the synthesis of enantiomerically pure compounds for medicinal chemistry.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	2-Methyl-Dl-Tryptophan
CAS No.	21495-41-0
Molecular Formula	C₁₂H₁₄N₂O₂
Molecular Weight	218.25 g/mol
Synonyms	DL-2-Methyltryptophan; (±)-2-Methyltryptophan; 2-Methyl-DL-tryptophan; α-Methyl-DL-tryptophan; (RS)-2-Methyltryptophan; 2-Methyltryptophan, DL-; 1H-Indole-3-propanoic acid, α-methyl-, (±)-; 2-Methyl-DL-α-aminohydrocinnamic acid
EINECS	Contact for details

Quality Control

Our 2-Methyl-Dl-Tryptophan is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-Ratio ~ 50:50
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.