Description

Orthoformic Acid Tri-tert-Butyl Ester is a specialized organometallic reagent and a protected form of orthoformic acid. This compound is valued for its role as a versatile tert-butoxycarbonylation agent and a key building block in complex organic synthesis. It is primarily sought by research and development laboratories, as well as production facilities in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing tert-butyl protecting groups.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where specific ester functionalities are required.
• Organic Synthesis Building Block: Serves as a tert-butoxycarbonyl (Boc) anion equivalent for nucleophilic substitution and carbon-carbon bond-forming reactions.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and monomers with tailored thermal and chemical properties.
• Material Science Research: Utilized in the development of novel organic frameworks and advanced coating materials.
• Laboratory Reagent: A high-purity chemical for method development and exploratory research in academic and industrial settings.

Basic Information

Product Name	Orthoformic Acid Tri-tert-Butyl Ester
CAS No.	21372-83-8
Molecular Formula	C13H28O3
Molecular Weight	232.36 g/mol
Synonyms	Tri-tert-butyl Orthoformate; tert-Butyl Orthoformate; Tris(tert-butoxy)methane; 1,1',1''-Methanetriyltris(2-methylpropan-2-ol); Orthoformic Acid Tris(1,1-dimethylethyl) Ester; Tris(tert-butoxy)methane; TBOT; (t-BuO)3CH
EINECS	Contact for details

Quality Control

Our Orthoformic Acid Tri-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments for research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.