Description

1-(Pyrimidin-2-Yl)-1,4-Diazepane (2Hcl) is a high-purity, nitrogen-rich heterocyclic building block and intermediate of significant interest in advanced organic synthesis. Its core value lies in its versatile diazepane-pyrimidine scaffold, which is crucial for constructing complex molecular architectures with targeted biological activity. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, enzyme inhibitors, and receptor modulators.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel herbicides, fungicides, or insecticides.
• Chemical Biology Probes: Utilized in the design and creation of molecular probes for studying biological pathways and protein functions.
• Ligand Synthesis for Catalysis: Can be employed to develop novel chelating ligands for transition metal catalysts used in asymmetric synthesis.
• Academic & Institutional R&D: A valuable reagent for universities and research institutes conducting fundamental research in heterocyclic and synthetic organic chemistry.

Basic Information

Item	Details
Product Name	1-(Pyrimidin-2-Yl)-1,4-Diazepane (2Hcl)
CAS No.	21279-58-3
Molecular Formula	C9H15Cl2N5
Molecular Weight	264.16 g/mol
Synonyms	1-(Pyrimidin-2-yl)-1,4-diazepane dihydrochloride; 1,4-Diazepane, 1-(2-pyrimidinyl)-, dihydrochloride; 2-(1,4-Diazepan-1-yl)pyrimidine dihydrochloride; 1-(1,4-Diazepan-1-yl)pyrimidine dihydrochloride; Pyrimidine-diazepane dihydrochloride adduct; 21279-58-3 (CAS); 1-Pyrimidin-2-yl-1,4-diazepane 2HCl
EINECS	Contact for details

Quality Control

Our 1-(Pyrimidin-2-Yl)-1,4-Diazepane (2Hcl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.