Description

(R)-Thiopentone CAS NO 21045-47-6 is the single enantiomer of the potent ultra-short-acting barbiturate anesthetic, thiopental. This specific stereoisomer is of significant interest in advanced pharmacological research and development due to its distinct pharmacokinetic and pharmacodynamic profile compared to the racemic mixture or the (S)-enantiomer. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing novel anesthetic agents, studying receptor-specific interactions, and producing high-purity reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified high-purity standard for analytical method development, validation, and quality control testing of anesthetic formulations.
• Stereoselective Pharmacological Research: Used in preclinical studies to investigate the enantiomer-specific mechanisms of action, metabolic pathways, and side-effect profiles of barbiturate anesthetics.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a key chiral building block in the synthesis of advanced, enantiomerically pure anesthetic drugs and related central nervous system (CNS) agents.
• Biochemical & Neurochemical Studies: Employed in in vitro assays to study ligand-receptor binding at GABAA receptors and other neuronal targets to understand anesthetic action at the molecular level.
• Metabolite Identification & Toxicology: Utilized in metabolism studies to identify and characterize the specific metabolites generated from the (R)-enantiomer, aiding in safety and toxicology assessments.

Basic Information

Product Name	(R)-Thiopentone
CAS No.	21045-47-6
Molecular Formula	C11H18N2O2S
Molecular Weight	242.34 g/mol
Synonyms	(R)-Thiopental; (R)-Thiopentobarbital; (R)-Penthiobarbital; (5R)-5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid; (R)-Thiomebumal; (R)-Thionembutal; (R)-Trapanal; Enantiomer of Thiopentone
EINECS	Contact for details

Quality Control

Our (R)-Thiopentone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for key parameters including assay, chiral purity, related substances, and residual solvents. We support compliance with relevant pharmacopeial guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.