Description

Caerulein (Desulfated) is a synthetic analog of the naturally occurring decapeptide hormone, modified by the removal of the sulfate group from the tyrosine residue. This modification alters its receptor binding affinity and biological activity profile, making it a valuable tool for pharmacological and biochemical research. It is primarily utilized by research institutions and pharmaceutical companies investigating gastrointestinal physiology, pancreatic secretion, and cholecystokinin receptor signaling pathways.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of cholecystokinin (CCK) receptor subtypes (CCKA and CCKB).
• Gastrointestinal Studies: Investigation of pancreatic enzyme secretion, gallbladder contraction, and gut motility.
• Neuroscience Research: Exploring the role of CCK-related peptides in satiety, anxiety, and nociception.
• Biochemical Assay Development: Serves as a critical component in receptor binding assays and functional cell-based tests.
• Peptide Chemistry Reference: Used as a model compound in studying structure-activity relationships (SAR) of peptide hormones.

Basic Information

Product Name	Caerulein (Desulfated)
CAS No.	20994-83-6
Molecular Formula	C58H73N13O21S2
Molecular Weight	1352.4 g/mol
Synonyms	Desulfated Caerulein; Ceruletide (Desulfated); Caerulein Desulfate; pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2 (Desulfated); CGK-1 (Desulfated); CCK-8 (Desulfated Analog); Cholecystokinin Octapeptide (CCK-8) Desulfated; Tyrosine-Desulfated Caerulein
EINECS	Contact for details

Quality Control

Our Caerulein (Desulfated) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.