Description

Z-Ser(Bzl)-OH is a protected serine derivative, specifically the benzyl (Bzl) ether of the side-chain hydroxyl group, with the free carboxylic acid functional group. This compound is a crucial building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and reactivity during solid-phase and solution-phase peptide coupling. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, bioactive probes, and advanced materials. The product is supplied to meet the stringent purity requirements of modern organic and medicinal chemistry applications.

Application

• Peptide Synthesis: A fundamental protected amino acid for the stepwise construction of peptide chains in both research and process development.
• Pharmaceutical Intermediates: Serves as a key chiral intermediate in the production of active pharmaceutical ingredients (APIs) with serine motifs.
• Bioconjugation & Probe Development: Used to incorporate serine residues into fluorescent tags, affinity labels, and other molecular probes for biochemical studies.
• Combinatorial Chemistry: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Material Science: Acts as a monomer or modifying agent for creating specialized polymers and biomimetic materials.

Basic Information

Product Name	Z-Ser(Bzl)-OH
CAS No.	20806-43-3
Molecular Formula	C18H19NO5
Molecular Weight	329.35 g/mol
Synonyms	N-Carbobenzoxy-O-benzyl-L-serine; Z-O-Benzyl-L-serine; N-(Benzyloxycarbonyl)-O-benzyl-L-serine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-(phenylmethoxy)propanoic acid; Z-Ser(Bzl); CBZ-O-Benzyl-L-serine; L-Serine, N-[(phenylmethoxy)carbonyl]-, 3-(phenylmethyl) ether; Benzyl N-[(benzyloxy)carbonyl]-L-seryl ether
EINECS	Contact for details

Quality Control

Our Z-Ser(Bzl)-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), optical rotation, and other critical parameters is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-10.0° to -12.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.