Description

Methyl 4-Trifluoromethylcinnamate is a high-value fluorinated cinnamate ester, serving as a versatile and critical building block in advanced organic synthesis. Its core value lies in the introduction of the trifluoromethyl group, which significantly alters the physicochemical properties of target molecules, enhancing their metabolic stability, lipophilicity, and bioavailability. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require precise fluorination to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in areas like kinase inhibitors, anti-inflammatory agents, and CNS-active compounds where the CF₃ group is advantageous.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl moiety can improve biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer & Specialty Chemicals: Incorporated as a monomer or modifier to create polymers with unique surface properties, chemical resistance, and optical characteristics.
• Chemical Research & Development: Employed in academic and industrial R&D for method development in cross-coupling reactions, fluorination chemistry, and as a standard for analytical purposes.
• Fluorine Chemistry Building Block: Utilized in the synthesis of more complex, multi-fluorinated compounds for various high-tech applications.

Basic Information

Product Name	Methyl 4-Trifluoromethylcinnamate
CAS No.	20754-22-7
Molecular Formula	C₁₁H₉F₃O₂
Molecular Weight	230.18 g/mol
Synonyms	Methyl (E)-3-[4-(trifluoromethyl)phenyl]acrylate; Methyl (E)-3-(4-Trifluoromethylphenyl)propenoate; (E)-Methyl 3-(4-(Trifluoromethyl)phenyl)acrylate; 4-Trifluoromethylcinnamic Acid Methyl Ester; Methyl p-Trifluoromethylcinnamate; (E)-Methyl 4-(Trifluoromethyl)cinnamate; trans-Methyl 4-Trifluoromethylcinnamate; Methyl α,4-Bis(trifluoromethyl)cinnamate (incorrect but common search variant)
EINECS	Contact for details

Quality Control

Our Methyl 4-Trifluoromethylcinnamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and isomeric consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound is stable under inert atmosphere but should be kept away from strong oxidizing agents and bases. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0% (Area %)
Isomeric Purity (E/Z Ratio)	≥ 99:1 (E/Z)
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.