Description

Tobramycin A CAS NO 20744-51-8 is a potent aminoglycoside antibiotic derived from *Streptomyces tenebrarius*. This high-purity compound is critical for pharmaceutical research and development, offering reliable efficacy against a broad spectrum of Gram-negative bacteria. It is an essential raw material for manufacturers in the pharmaceutical industry, particularly for producing ophthalmic solutions, inhalation therapies, and injectable formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of antibiotic formulations, including injectables and topical solutions.
• Ophthalmic Preparations: Key component in eye drops and ointments for treating bacterial conjunctivitis and other ocular infections.
• Inhalation Therapy: Used in nebulizer solutions for managing chronic pulmonary infections in conditions like cystic fibrosis.
• Veterinary Medicine: Employed in antibiotic treatments for bacterial infections in animals.
• Microbiological Research: Serves as a standard and selective agent in antimicrobial susceptibility testing and microbiological assays.
• Reference Standard: Used as a certified reference material (CRM) in quality control laboratories for HPLC and other analytical methods.

Basic Information

Product Name	Tobramycin A
CAS No.	20744-51-8
Molecular Formula	C₁₈H₃₇N₅O₉
Molecular Weight	467.52 g/mol
Synonyms	Tobramycin; Nebcin; Tobra; TOBI; Tobrex; (2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxy-D-streptamine; Antibiotic 65-322; Gernebcin
EINECS	244-040-1

Quality Control

Our Tobramycin A is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure identity, potency, and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC, anhydrous basis)	95.0% - 102.0%
pH (1% solution)	9.0 - 11.0
Specific Rotation	+138° to +148°
Water Content (KF)	≤ 8.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 2.0% Total impurities ≤ 5.0%
Bacterial Endotoxins	< 1.0 EU/mg
Microbial Enumeration Tests	Conforms to EP/USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.