Description

H-Val-Ile-Oh CAS NO 20556-14-3 is a high-purity dipeptide derivative, specifically the C-terminal carboxylic acid of the valine-isoleucine sequence. This compound serves as a critical building block (protected peptide fragment) in solid-phase and solution-phase peptide synthesis, enabling the precise construction of complex polypeptides and proteins. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutic peptides, biochemical probes, and bioactive materials.

Application

• Pharmaceutical Intermediate: Key raw material for the synthesis of longer therapeutic peptide sequences targeting metabolic disorders, cardiovascular diseases, and oncology.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, structure-activity relationship (SAR) investigations, and proteomics research.
• Peptide Library Construction: Essential building block for generating combinatorial peptide libraries used in high-throughput screening for drug discovery.
• Cosmeceutical Peptides: Potential intermediate in the synthesis of bioactive peptides for anti-aging, moisturizing, or skin-repair cosmetic formulations.
• Academic Synthesis: A valuable teaching and research tool in university chemistry and biochemistry departments for demonstrating peptide coupling techniques.
• API Development: Serves as a fragment in the convergent synthesis of complex Active Pharmaceutical Ingredients (APIs) that are peptide-based.

Basic Information

Product Name	H-Val-Ile-Oh
CAS No.	20556-14-3
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	Val-Ile; L-Valyl-L-isoleucine; H-Val-Ile-OH; Valine-Isoleucine; V-I; L-Val-L-Ile; N-(2-Amino-3-methylbutanoyl)-L-isoleucine; (2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our H-Val-Ile-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure stereochemical integrity, meeting the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.