Description

Prolyl-Prolyl-Alanine is a high-purity tripeptide composed of two proline residues and one alanine. This specific sequence is of significant interest in biochemical research and pharmaceutical development due to its role in studying peptide stability, enzyme specificity, and collagen-like structures. It serves as a critical building block and reference standard for researchers and manufacturers in advanced life science sectors. Key industries that utilize this compound include pharmaceutical R&D, proteomics, and specialized chemical synthesis.

Application

• Pharmaceutical Research & Development: Used as a reference standard, intermediate, or substrate in the study of proteolytic enzymes like prolyl oligopeptidase.
• Biochemical Assays: Serves as a model peptide for investigating peptide bond stability, folding kinetics, and structure-activity relationships (SAR).
• Proteomics & Peptide Synthesis: Acts as a building block in solid-phase peptide synthesis (SPPS) for creating longer, more complex peptide sequences.
• Academic Research: Employed in university and institutional labs for fundamental studies on collagen mimetics and peptide-based materials.
• Quality Control Standards: Utilized as a high-purity calibrant or control in analytical laboratories for method development and validation.

Basic Information

Product Name	Prolyl-Prolyl-Alanine
CAS No.	20535-43-7
Molecular Formula	C13H21N3O4
Molecular Weight	283.33 g/mol
Synonyms	PPA; Pro-Pro-Ala; L-Prolyl-L-prolyl-L-alanine; (S)-2-((S)-1-((S)-1-Carboxyethylamino)-1-oxopropan-2-yl)pyrrolidine-2-carboxamide; Ala-Pro-Pro (reverse sequence); Tripeptide PPA; Proline-Proline-Alanine
EINECS	Contact for details

Quality Control

Our Prolyl-Prolyl-Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.