Description

Melittin is a potent, naturally occurring peptide and the primary active component of honeybee (*Apis mellifera*) venom. This compound is of significant interest due to its powerful hemolytic and antimicrobial properties, making it a valuable research tool in biochemistry and pharmacology. It is primarily utilized by researchers in the life sciences, pharmaceutical development, and biotechnology sectors for studying membrane interactions, cytolytic mechanisms, and as a lead compound for novel therapeutic agents.

Application

• Biomedical Research: Fundamental studies on cell membrane lysis, pore formation, and mechanisms of cytolytic peptides.
• Pharmacology & Drug Discovery: Investigation as a potential scaffold or lead compound for developing new antimicrobial, anti-inflammatory, or anti-cancer agents.
• Biochemistry & Cell Biology: Used as a tool to permeabilize cell membranes (e.g., for patch-clamp experiments) or to study signal transduction pathways.
• Toxicology Studies: Serves as a reference standard and active agent in studies related to bee venom toxicity and allergy research.
• Peptide Chemistry & Synthesis: A model peptide for studying structure-activity relationships (SAR) and for benchmarking analytical methods in peptide characterization.

Basic Information

Product Name	Melittin
CAS No.	20499-79-0
Molecular Formula	C₁₃₁H₂₂₉N₃₉O₃₁
Molecular Weight	2846.5 g/mol
Synonyms	Melittin I; Bee Venom Peptide; Apitoxin; Apidermin; Apamin-free Melittin; 26-L-Lysine-27-L-arginine-melittin; Honeybee Venom Basic Peptide; Melittin (Honeybee); NSC 106977
EINECS	243-862-1

Quality Control

Our Melittin is produced and tested under stringent quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to relevant industry best practices to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, aqueous buffers, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.