Description

2',3'-o-Isopropylidene 5-Hydroxyuridine is a key protected nucleoside derivative, serving as a critical synthetic intermediate in the production of modified RNA and DNA analogs. Its value lies in providing a stable, reactive scaffold for the controlled introduction of functional groups at the 5-position of the uracil base. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating antiviral and anticancer nucleoside prodrugs, as well as in biochemical research for oligonucleotide synthesis and probe development.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA strands for research and therapeutic applications.
• Biochemical Probe Development: Serves as a precursor for fluorescently labeled or otherwise tagged nucleosides used in molecular biology assays.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by allowing modifications at the 5-position of uridine.
• Process Chemistry: Employed in the scalable production of active pharmaceutical ingredients (APIs) requiring protected nucleoside intermediates.

Basic Information

Product Name	2',3'-o-Isopropylidene 5-Hydroxyuridine
CAS No.	20406-82-0
Molecular Formula	C₁₂H₁₆N₂O₆
Molecular Weight	284.26 g/mol
Synonyms	5-Hydroxy-2',3'-O-isopropylideneuridine; 5-Hydroxyuridine 2',3'-acetonide; 2',3'-O-(1-Methylethylidene)-5-hydroxyuridine; 5-Hydroxy-2',3'-O-(1-methylethylidene)uridine; Isopropylidene 5-hydroxyuridine; 5-OH-2',3'-O-isopropylideneuridine; 2',3'-O-Isopropylidene-5-hydroxyuridine; 5-Hydroxy-2',3'-O-(propan-2-ylidene)uridine
EINECS	Contact for details

Quality Control

Our 2',3'-o-Isopropylidene 5-Hydroxyuridine is produced under a rigorous quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccant packs.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.