Description

R-(-)-Norapomorphine Hydrochloride is a high-purity, enantiomerically pure chemical compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and reference standard for studying dopaminergic systems and neurological pathways. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in neuroscience, pharmacology, and the development of central nervous system (CNS) therapeutics. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant and control material in analytical method development and validation for quality control laboratories.
• Neuroscience Research: Acts as a key pharmacological tool for in vitro and in vivo studies targeting dopamine receptors, aiding in the understanding of Parkinson's disease, schizophrenia, and addiction mechanisms.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a chiral synthon in the multi-step synthesis of complex drug candidates targeting the central nervous system.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) campaigns and binding assays to identify and characterize novel therapeutic compounds.
• Metabolite Studies: Used in pharmacokinetic and metabolic stability studies to understand the biotransformation pathways of apomorphine and related analogs.

Basic Information

Product Name	R-(-)-Norapomorphine Hydrochloride
CAS No.	20382-69-8
Molecular Formula	C₁₆H₁₇NO₂ • HCl
Molecular Weight	291.77 g/mol (Free base: 255.31 g/mol)
Synonyms	(-)-Norapomorphine HCl; (R)-Norapomorphine Hydrochloride; 6aβ-Aporphine-10,11-diol Hydrochloride; R-(-)-10,11-Dihydroxyaporphine Hydrochloride; Norapomorphine HCl; (6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol Hydrochloride
EINECS	Contact for details

Quality Control

Our R-(-)-Norapomorphine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) providing results for assay, chiral purity, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.