Description

Phenylazobenzyloxycarbonyl-Prolyl-Leucyl-Glycyl-Prolyl-Arginine is a synthetic peptide derivative, often utilized as a specialized biochemical tool and research compound. Its value lies in its role as a chromogenic substrate for the study and detection of specific proteolytic enzymes, particularly collagenases and gelatinases. This makes it an essential reagent for researchers and developers in the fields of biochemical research, pharmaceutical development, and diagnostic assay design, where precise enzyme activity measurement is critical.

Application

• Enzyme Substrate for Research: Primary use as a chromogenic peptide substrate for in vitro assays targeting matrix metalloproteinases (MMPs) like collagenase and gelatinase.
• Biochemical Pathway Analysis: Employed in laboratory studies to investigate enzyme kinetics, inhibition, and proteolytic pathways.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) platforms to identify and evaluate potential therapeutic enzyme inhibitors.
• Diagnostic Development: Serves as a key component in developing colorimetric or spectrophotometric diagnostic kits for enzyme activity detection.
• Tissue Remodeling & Disease Research: Applied in research models studying conditions involving extracellular matrix degradation, such as cancer metastasis, arthritis, and wound healing.
• Quality Control Reagent: Can be used as a reference standard or control in the production and validation of other enzymatic reagents.

Basic Information

Product Name	Phenylazobenzyloxycarbonyl-Prolyl-Leucyl-Glycyl-Prolyl-Arginine
CAS No.	20283-89-0
Molecular Formula	C46H64N12O10
Molecular Weight	945.1 g/mol
Synonyms	Pz-Pro-Leu-Gly-Pro-Arg; Pz-PLGPR; 4-Phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg; PAB-Pro-Leu-Gly-Pro-Arg; Chromogenic Substrate for Collagenase; MMP Substrate; Azobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg; Pz-Pro-Leu-Gly-Pro-Arg-OH
EINECS	Contact for details

Quality Control

Our Phenylazobenzyloxycarbonyl-Prolyl-Leucyl-Glycyl-Prolyl-Arginine is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.