Description

Dl-2-Amino-4-Phosphonobutyric Acid CAS NO 20263-07-4 is a phosphonic acid derivative of the excitatory amino acid glutamate, serving as a potent and selective antagonist of metabotropic glutamate receptors (mGluRs). This compound is critical for neuroscience research, enabling the study of glutamatergic signaling pathways and their roles in neurological function and disease. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biochemical manufacturers focused on neuropharmacology and central nervous system (CNS) drug discovery.

Application

• Neuroscience Research: A key pharmacological tool for studying Group I and II metabotropic glutamate receptor (mGluR) subtypes in synaptic transmission and plasticity.
• Neuropharmacology: Used in the development and screening of novel therapeutic agents targeting neurological disorders such as epilepsy, anxiety, and chronic pain.
• Biochemical Assays: Serves as a reference standard and active agent in in vitro and in vivo models to elucidate glutamate's role in CNS pathophysiology.
• Academic & Institutional R&D: Essential for basic research in university and government laboratories investigating excitatory amino acid receptors and neuronal signaling cascades.
• Pharmaceutical Intermediate: Can be utilized in the synthetic pathways for more complex receptor modulators or diagnostic probes.

Basic Information

Product Name	Dl-2-Amino-4-Phosphonobutyric Acid
CAS No.	20263-07-4
Molecular Formula	C₄H₁₀NO₅P
Molecular Weight	183.10 g/mol
Synonyms	DL-AP4; DL-2-Amino-4-phosphonobutanoic Acid; (±)-2-Amino-4-phosphonobutyric Acid; APB; (RS)-2-Amino-4-phosphonobutanoic Acid; AMPB; DL-2-Amino-4-phosphono-butanoate; Glutamate metabotropic receptor antagonist AP4
EINECS	Contact for details

Quality Control

Our Dl-2-Amino-4-Phosphonobutyric Acid is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the exacting standards required for advanced research applications. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identification, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.