Description

Z-Gly-Gly-Gly-Gly-Gly-Oh CAS NO 20228-72-2 is a high-purity, synthetic pentaglycine peptide derivative, protected at the N-terminus with a benzyloxycarbonyl (Z) group. This compound serves as a crucial building block and intermediate in advanced peptide synthesis and biochemical research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require precise and reliable peptide fragments for drug discovery, proteomics, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected fragment for the sequential assembly of longer, complex peptide chains.
• Bioconjugation and Linker Chemistry: Used to introduce a polyglycine spacer arm for attaching drugs, labels, or other molecules to proteins, antibodies, or surfaces.
• Enzyme Substrate and Inhibitor Development: Serves as a model substrate for studying protease and peptidase enzyme activity, kinetics, and inhibition.
• Biomaterial and Hydrogel Research: Incorporated into synthetic polymers to create biofunctional materials with tailored cell-adhesion or degradation properties.
• Antibiotic Research: Acts as a synthetic analog for studying bacterial cell wall biosynthesis and developing new antimicrobial agents.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes for profiling enzyme families in complex biological samples.
• Reference Standard and Calibration: Provides a high-purity standard for analytical method development and quality control in peptide production.

Basic Information

Product Name	Z-Gly-Gly-Gly-Gly-Gly-Oh
CAS No.	20228-72-2
Molecular Formula	C₂₂H₃₁N₇O₈
Molecular Weight	521.53 g/mol
Synonyms	Nα-Benzyloxycarbonyl-pentaglycine; Z-Pentaglycine; Z-GGGGG-OH; Benzyloxycarbonyl-glycyl-glycyl-glycyl-glycyl-glycine; N-CBZ-Pentaglycine; CBZ-Gly-Gly-Gly-Gly-Gly-OH; Nα-Carbobenzoxy-pentaglycine; Nα-Z-Gly-Gly-Gly-Gly-Gly-OH
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-Gly-Gly-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the stringent requirements of research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Conforms to ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.