Description

(S)-Thiamylal is a short-acting barbiturate derivative and the pharmacologically active enantiomer of thiamylal. This compound is a critical chiral intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in the synthesis, quality control, and metabolic studies of anesthetic agents. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for your research needs.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control (QC/QA) testing of thiamylal-based products.
• Chiral Intermediate: Serves as a key building block in the enantioselective synthesis of novel barbiturate derivatives and related central nervous system (CNS) agents.
• Pharmacological Research: Employed in in vitro and in vivo studies to investigate the mechanism of action, receptor binding, and metabolic pathways of ultrashort-acting barbiturates.
• Forensic and Clinical Toxicology: Acts as a calibration standard in mass spectrometry (LC-MS/MS, GC-MS) for the accurate identification and quantification of thiamylal in biological matrices.
• Impurity Profiling: Used to identify and quantify the (S)-enantiomer as a potential impurity in racemic thiamylal or related pharmaceutical formulations.

Basic Information

Product Name	(S)-Thiamylal
CAS No.	20224-46-8
Molecular Formula	C12H18N2O2S
Molecular Weight	254.35 g/mol
Synonyms	5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid (S-enantiomer); (5S)-5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid; Thiamylal (S-isomer); (S)-5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid; (S)-Thioseconal; NSC 77370; Surital (S-enantiomer)
EINECS	Contact for details

Quality Control

Every batch of (S)-Thiamylal is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to support your regulatory and research requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as enantiomeric purity, chemical purity (by HPLC), and identification. Our quality system ensures traceability and compliance with relevant industry standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (S-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.