Description

H-Asp(His-Oh)-Oh is a protected dipeptide derivative, specifically an aspartic acid derivative with a histidine side chain, identified by CAS No. 20223-80-7. This compound serves as a crucial building block in advanced organic synthesis, particularly for the construction of complex peptides and peptidomimetics. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development projects.

Application

• Pharmaceutical Intermediates: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce specific amino acid sequences.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Research & Development: Employed in academic and industrial R&D for studying enzyme-substrate interactions and protein engineering.
• Biomimetic Materials: Serves as a component in the design of biomimetic polymers and hydrogels for medical applications.
• Catalyst Development: Potential use in designing chiral catalysts or ligands for asymmetric synthesis.

Basic Information

Item	Details
Product Name	H-Asp(His-Oh)-Oh
CAS No.	20223-80-7
Molecular Formula	C10H15N5O5
Molecular Weight	285.26 g/mol
Synonyms	Aspartic acid derivative with histidine; N-[(1H-Imidazol-4-yl)methyl]-L-asparagine; L-Aspartic acid, N-[(1H-imidazol-4-yl)methyl]-; H-Asp(His)-OH; Asp-His dipeptide derivative; Protected Asp-His-OH; (2S)-2-[[(1H-Imidazol-4-yl)methyl]amino]-3-carboxypropanamide; CAS 20223-80-7
EINECS	Contact for details

Quality Control

Our H-Asp(His-Oh)-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets high-purity standards suitable for research and synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.