Description

4-Aminophenylsulfur Pentafluoride is a specialized organofluorine compound featuring a pentafluorosulfur (-SF5) group, a highly electronegative and lipophilic substituent. This unique structure makes it a valuable building block in advanced material science and pharmaceutical research, where it is used to dramatically alter the electronic and physical properties of target molecules. It is particularly sought after by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty polymer industries for creating novel compounds with enhanced metabolic stability, bioavailability, and material characteristics.

Application

• Pharmaceutical Intermediate: Key synthon for introducing the -SF5 pharmacophore into drug candidates to improve lipophilicity, metabolic stability, and membrane permeability.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the -SF5 group can enhance biological activity and environmental persistence.
• Advanced Material Precursor: Serves as a monomer or functionalization agent for high-performance polymers, liquid crystals, and electronic materials requiring specific dielectric or surface properties.
• Ligand and Catalyst Development: Employed to create novel ligands for catalysis, leveraging the strong electron-withdrawing nature of the -SF5 group to tune metal center reactivity.
• Fluorine Chemistry & Library Synthesis: A crucial reagent for medicinal and combinatorial chemists building diverse compound libraries to explore new chemical space.

Basic Information

Product Name	4-Aminophenylsulfur Pentafluoride
CAS No.	2993-24-0
Molecular Formula	C6H6F5NS
Molecular Weight	219.18 g/mol
Synonyms	4-Aminophenylsulfur Pentafluoride; 4-Aminopentafluorosulfanylbenzene; p-Aminophenylsulfur Pentafluoride; 4-SF5-Aniline; 1-Amino-4-(pentafluoro-λ6-sulfanyl)benzene; 4-(Pentafluorosulfanyl)aniline; 4-Amino-1-(pentafluorosulfanyl)benzene; CAS 2993-24-0
EINECS	Contact for details

Quality Control

Our 4-Aminophenylsulfur Pentafluoride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.