Description

3-Aminophenylsulfur Pentafluoride is a specialized organofluorine building block featuring a reactive amino group and a stable sulfur pentafluoride (SF5) moiety. This unique structure makes it a high-value intermediate for introducing the highly lipophilic and electron-withdrawing SF5 group into target molecules, significantly altering their physicochemical properties. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science seeking to enhance metabolic stability, bioavailability, and performance characteristics.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for creating SF5-substituted analogs with improved potency and pharmacokinetic profiles.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the SF5 group can contribute to enhanced biological activity and environmental stability.
• Liquid Crystal & Electronic Materials: Serves as a precursor for advanced functional materials, including liquid crystals for displays and charge-transport materials for organic electronics, due to the strong dipole and steric bulk of the SF5 group.
• Coordination Chemistry & Ligand Design: The aniline nitrogen allows for the creation of novel ligands for catalysis or metal-organic frameworks (MOFs), with the SF5 group modifying solubility and electronic properties.
• Fluorine-Containing Polymer Modifiers: Employed to incorporate fluorine into polymer backbones or side chains, imparting valuable characteristics such as chemical resistance, low surface energy, and thermal stability.
• Research & Development: A critical reagent in academic and industrial R&D for exploring structure-activity relationships (SAR) and developing new chemical entities across multiple high-tech sectors.

Basic Information

Product Name	3-Aminophenylsulfur Pentafluoride
CAS No.	2993-22-8
Molecular Formula	C6H6F5NS
Molecular Weight	219.18 g/mol
Synonyms	3-Aminophenylsulfur Pentafluoride; 3-Aminopentafluorosulfanylbenzene; 3-(Pentafluorosulfanyl)aniline; 3-SF5-Aniline; Benzenamine, 3-(pentafluoro-λ⁶-sulfanyl)-; 3-Aminophenyl SF5; 3-(Amino)phenylsulfur pentafluoride; 1-Amino-3-(pentafluorosulfanyl)benzene
EINECS	Contact for details

Quality Control

Our 3-Aminophenylsulfur Pentafluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.