Description

2,4-Dichloro-5-Pyrimidinecarbonyl Chloride is a highly reactive and versatile pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the acid chloride and chloropyrimidine groups enable sequential and site-specific modifications. This compound is essential for research chemists and process developers in the pharmaceutical and agrochemical industries, particularly for constructing complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that contain a pyrimidine core.
• Material Science Research: Employed in the development of organic semiconductors, ligands for metal-organic frameworks (MOFs), and functional polymers.
• Chemical Biology: Acts as a derivatization agent or a coupling partner for creating molecular probes and bioconjugates.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects and the scalable production of specialty chemicals.

Basic Information

Product Name	2,4-Dichloro-5-Pyrimidinecarbonyl Chloride
CAS No.	2972-52-3
Molecular Formula	C5HCl3N2O
Molecular Weight	211.43 g/mol
Synonyms	5-Pyrimidinecarbonyl chloride, 2,4-dichloro-; 2,4-Dichloropyrimidine-5-carbonyl chloride; 2,4-Dichloro-5-pyrimidine carboxylic acid chloride; 2,4-Dichloropyrimidine-5-carboxylic acid chloride; 5-(Chlorocarbonyl)-2,4-dichloropyrimidine; NSC 403697
EINECS	220-990-5

Quality Control

Our 2,4-Dichloro-5-Pyrimidinecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.