Description

3,4-Bis-Trifluoromethyl-Phenylamine is a high-value aromatic amine derivative featuring two trifluoromethyl groups, which impart unique electronic and steric properties. This compound is a critical pharmaceutical intermediate and agrochemical building block, prized for its ability to enhance the metabolic stability and lipophilicity of target molecules. It is primarily utilized by R&D chemists and process development teams in the life sciences and advanced materials sectors for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl groups improve biological activity and environmental persistence.
• Material Science: Serves as a monomer or precursor for specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic components.
• Organic Synthesis & Catalysis: Acts as a ligand precursor or a sterically hindered aniline in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination).
• Dye & Pigment Industry: Intermediate for manufacturing high-performance, light-fast fluorinated dyes and pigments.
• Research & Development: Essential reference standard and starting material in academic and industrial R&D for exploring new chemical entities.

Basic Information

Product Name	3,4-Bis-Trifluoromethyl-Phenylamine
CAS No.	2965-07-3
Molecular Formula	C8H5F6N
Molecular Weight	229.12 g/mol
Synonyms	3,4-Bis(trifluoromethyl)aniline; 3,4-Bis(trifluoromethyl)benzenamine; 3,4-Di(trifluoromethyl)aniline; 3,4-Di(trifluoromethyl)phenylamine; 3,4-Bis(trifluoromethyl)phenylamine; α,α,α,α',α',α'-Hexafluoro-3,4-xylidine; 3,4-Bis(trifluoromethyl)aminobenzene; Benzenamine, 3,4-bis(trifluoromethyl)-
EINECS	220-985-9

Quality Control

Our 3,4-Bis-Trifluoromethyl-Phenylamine is manufactured under a cGMP-compliant quality management system to ensure batch-to-batch consistency and traceability. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. Comprehensive Certificates of Analysis (COA) detailing purity, residual solvents, and heavy metal content are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.