Description

3-Carboxymethylhistidine is a modified amino acid derivative of histidine, featuring an additional carboxymethyl group on the imidazole ring. This structural modification makes it a valuable intermediate and building block in advanced biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications ranging from peptide synthesis to the study of protein modifications and enzyme mechanisms.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel peptides and potential therapeutic agents.
• Biochemical Research: Used as a standard or reagent in studies of protein glycation, advanced glycation end-products (AGEs), and related metabolic pathways.
• Proteomics & Metabolomics: Acts as a reference compound for the identification and quantification of post-translational modifications in complex biological samples.
• Enzyme Substrate Analog: Employed in enzymatic studies to investigate substrate specificity and inhibition mechanisms of histidine-related enzymes.
• Nutritional Science Research: Utilized in studies exploring the bioavailability and metabolic fate of modified amino acids.
• Diagnostic Reagent Development: A potential component in the development of assays for detecting specific biomarkers related to oxidative stress or metabolic disorders.

Basic Information

Product Name	3-Carboxymethylhistidine
CAS No.	2930-79-2
Molecular Formula	C9H13N3O4
Molecular Weight	227.22 g/mol
Synonyms	3-Carboxymethyl-L-histidine; N(τ)-Carboxymethylhistidine; CM-His; Nτ-Carboxymethyl-L-histidine; (2S)-2-Amino-3-[1-(carboxymethyl)-1H-imidazol-5-yl]propanoic acid; L-Histidine, N-(carboxymethyl)-; Tau-Carboxymethylhistidine
EINECS	220-904-1

Quality Control

Our 3-Carboxymethylhistidine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (HPLC), chiral purity, and impurity profiles. Our quality commitment aligns with the standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% L-isomer
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.