Description

S-Methylglutathione is a modified tripeptide and a key derivative of the essential cellular antioxidant glutathione. This compound is of significant interest in biochemical research and pharmaceutical development due to its role in studying methylation pathways and cellular redox regulation. It serves as a crucial intermediate and reference standard for scientists and manufacturers in the life sciences, pharmaceutical, and nutraceutical industries.

Application

• Biochemical Research: Used as a reference standard and substrate in enzymatic studies related to glutathione metabolism and methylation processes.
• Pharmaceutical Development: Investigated as a potential precursor or active pharmaceutical ingredient (API) in formulations targeting oxidative stress.
• Metabolomics & Proteomics: Serves as a critical analytical standard for the identification and quantification of methylated glutathione species in complex biological samples.
• Nutraceutical Research: Studied for its potential bioactivity and stability advantages compared to native glutathione in supplement formulations.
• Enzyme Inhibition Studies: Utilized to study the mechanism and inhibition of glutathione S-transferases (GSTs) and related enzymes.
• Cell Culture & In Vitro Assays: Applied in media supplements or as a treatment compound to modulate intracellular redox status in experimental models.

Basic Information

Product Name	S-Methylglutathione
CAS No.	2922-56-7
Molecular Formula	C11H19N3O6S
Molecular Weight	321.35 g/mol
Synonyms	L-γ-Glutamyl-S-methyl-L-cysteinylglycine; S-Methyl-L-glutathione; Glutathione, S-methyl-; Methylglutathione; NSC 113236; (2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-(methylsulfanyl)ethyl]carbamoyl}butanoic acid
EINECS	220-874-4

Quality Control

Our S-Methylglutathione is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.