Description

Cyclo(-Leu-Pro) CAS NO 2873-36-1 is a cyclic dipeptide, also known as a diketopiperazine (DKP), formed from the amino acids L-leucine and L-proline. This compound is of significant interest in pharmaceutical research and development due to its role as a key structural motif and potential pharmacophore. It serves as a crucial intermediate and building block for researchers in medicinal chemistry, peptide science, and biochemistry. The product is essential for synthesizing more complex molecules, studying biological activity, and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold for the synthesis of novel drug candidates and bioactive molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize peptide-based therapeutics.
• Biochemical Tool Compound: Employed in proteomics and enzymology research to study enzyme inhibition or receptor binding.
• Peptide Mimetic Development: Acts as a stable, conformationally restricted template for designing peptide mimics with enhanced metabolic stability.
• Cosmetic Peptide Synthesis: Potential use as a precursor for certain bioactive peptides used in cosmetic formulations.
• Academic & Industrial R&D: A fundamental reagent for laboratories exploring cyclic peptide libraries and new chemical entities.

Basic Information

Item	Detail
Product Name	Cyclo(-Leu-Pro)
CAS No.	2873-36-1
Molecular Formula	C11H18N2O2
Molecular Weight	210.27 g/mol
Synonyms	Cyclo(L-leucyl-L-prolyl); Cyclo(Leu-Pro); L-Leucyl-L-proline anhydride; 3-Benzyl-6-isopropylpiperazine-2,5-dione; DKPs (Leu-Pro); 2,5-Piperazinedione, 3-(2-methylpropyl)-6-(phenylmethyl)-, (3S,6S)-; Cyclo(L-Leu-L-Pro); Leu-Pro Diketopiperazine
EINECS	220-712-5

Quality Control

Our Cyclo(-Leu-Pro) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity analysis, and identity confirmation (IR, MS) to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation or clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by chiral HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.