Description

3-Chloro-L-Alanine is a halogenated derivative of the essential amino acid L-alanine, serving as a versatile chiral building block and enzyme inhibitor. This compound is valued for its role in biochemical research and pharmaceutical synthesis, particularly in the study of enzyme mechanisms and the development of active pharmaceutical ingredients (APIs). It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking high-purity, optically active intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel APIs and therapeutic agents.
• Biochemical Research: Used as a substrate analog and irreversible inhibitor for enzymes such as alanine racemase and D-amino acid transaminase.
• Agrochemical Synthesis: Serves as a precursor in the development of herbicides and pesticides with specific chiral activity.
• Peptide Chemistry: Incorporated into custom peptides to study structure-activity relationships or to create modified peptide therapeutics.
• Microbiology Studies: Employed in research to inhibit bacterial cell wall biosynthesis, aiding in antimicrobial discovery.
• Diagnostic Reagent Development: Used in the formulation of enzymatic assays and diagnostic kits.

Basic Information

Product Name	3-Chloro-L-Alanine
CAS No.	2731-73-9
Molecular Formula	C3H6ClNO2
Molecular Weight	123.54 g/mol
Synonyms	(S)-2-Amino-3-chloropropanoic acid; L-3-Chloroalanine; β-Chloro-L-alanine; (S)-3-Chloroalanine; Chloroalanine; L-β-Chloroalanine; NSC 132954; 3-Chloro-L-α-alanine
EINECS	220-350-7

Quality Control

Our 3-Chloro-L-Alanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Specific Rotation	[α]20/D: -10° to -14° (c=1 in 1N HCl)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.