Description

L-Proline, [U-14C] is a uniformly carbon-14 labeled isotopologue of the essential amino acid L-proline, identified by CAS No. 2728-13-4. This radiochemical is a critical tool for metabolic pathway tracing and pharmacokinetic studies, offering high specific activity for sensitive detection. It is primarily required by pharmaceutical R&D laboratories, agrochemical companies, and academic research institutions conducting advanced studies in protein synthesis, plant physiology, and drug metabolism.

Application

• Metabolic Pathway Analysis: Used as a tracer to study proline metabolism, collagen biosynthesis, and stress response pathways in plants and animals.
• Drug Discovery & Development: Essential for conducting Absorption, Distribution, Metabolism, and Excretion (ADME) studies of proline-containing drug candidates.
• Biochemical Research: Serves as a labeled precursor in enzymatic assays and protein labeling experiments to investigate molecular mechanisms.
• Agricultural Science: Applied in research on plant stress tolerance, osmoregulation, and nitrogen utilization.
• Diagnostic Agent Development: Potential use in the research and development of novel Positron Emission Tomography (PET) tracers and other diagnostic probes.

Basic Information

Product Name	L-Proline, [U-14C]
CAS No.	2728-13-4
Molecular Formula	C5H914CO2H
Molecular Weight	~116.12 g/mol (unlabeled)
Synonyms	(S)-Pyrolidine-2-carboxylic-14C(U); L-2-Pyrrolidinecarboxylic-14C(U) Acid; (S)-(-)-Proline-14C(U); Proline-14C; L-Proline (U-14C); Uniformly Labeled Carbon-14 L-Proline; [U-14C]-L-Proline
EINECS	220-344-1 (for unlabeled L-Proline)

Quality Control

Every batch of L-Proline, [U-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Comprehensive testing includes radiochemical purity by HPLC, specific activity determination, and chemical identification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters for regulatory compliance and research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dry, inert atmosphere. Follow all applicable radiation safety guidelines and local regulations for handling and disposal.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% radiochemical purity
Specific Activity	50-60 mCi/mmol (Contact for current batch data)
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied in solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.