Description

4-n-Trifluoroacetamidophenol is a high-purity trifluoroacetylated aniline derivative, serving as a critical advanced intermediate in organic synthesis. Its value lies in providing a protected and activated aromatic amine group, enabling precise chemical transformations under controlled conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to build complex molecular architectures for active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those requiring trifluoromethylated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoroacetamide group influences bioavailability and stability.
• Organic Synthesis Reagent: Acts as a protected aniline precursor in multi-step synthesis, facilitating selective reactions at other sites on the aromatic ring.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with specific electronic properties.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	4-n-Trifluoroacetamidophenol
CAS No.	2709-93-5
Molecular Formula	C8H6F3NO2
Molecular Weight	205.13 g/mol
Synonyms	4-Hydroxy-N-(trifluoroacetyl)aniline; N-(4-Hydroxyphenyl)trifluoroacetamide; p-Trifluoroacetamidophenol; 4-Aminophenol trifluoroacetate; 4-(Trifluoroacetamido)phenol; 1-[4-Hydroxyphenyl]-2,2,2-trifluoroethanone imine; TFA-protected 4-aminophenol
EINECS	220-299-4

Quality Control

Our 4-n-Trifluoroacetamidophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, impurity profile, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.