Description

4-Fluoro-DL-Glutamic Acid is a fluorinated derivative of the amino acid glutamic acid, where a fluorine atom is strategically substituted on the carbon backbone. This modification is crucial for its role as a valuable biochemical tool and a key building block in medicinal chemistry research. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, metabolic studies, and drug discovery. The compound's unique structure allows it to act as a probe or inhibitor for glutamate-related enzymes and receptors.

Application

• Neuroscience Research: Used as a substrate analog or inhibitor in studies of glutamate transporters (EAATs) and receptors (e.g., NMDA, AMPA, kainate receptors).
• Enzyme Inhibition Studies: Serves as a probe for enzymes in glutamate metabolism, such as glutaminase and glutamate dehydrogenase.
• Pharmaceutical Intermediates: Acts as a key chiral synthon in the research and development of novel therapeutic agents targeting neurological disorders.
• Biochemical Assay Development: Employed in the design and validation of high-throughput screening assays for drug discovery pipelines.
• Metabolic Pathway Analysis: Used in isotopic labeling studies (e.g., with 18F or 19F NMR) to trace and understand metabolic fluxes in cells and tissues.
• Chemical Biology Probes: Incorporated into activity-based probes for profiling enzyme activities within complex biological systems.

Basic Information

Product Name	4-Fluoro-DL-Glutamic Acid
CAS No.	2708-77-2
Molecular Formula	C5H8FNO4
Molecular Weight	165.12 g/mol
Synonyms	DL-4-Fluoroglutamic Acid; (±)-4-Fluoroglutamic Acid; 4-Fluoro-DL-glutaminsäure; (RS)-4-Fluoroglutamic Acid; 2-Amino-4-fluoropentanedioic Acid; 4-Fluoro-2-aminopentanedioic Acid; NSC 334864; Fluoroglutamic Acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-DL-Glutamic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to verify the racemic mixture. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (DL Ratio)	~50:50 (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.