Description

Benzyloxycarbonylglycyl-L-Prolyl-L-Leucine CAS NO 2646-63-1 is a protected tripeptide derivative, widely utilized as a crucial synthetic intermediate in advanced organic and peptide chemistry. Its primary value lies in providing a versatile building block for the controlled synthesis of more complex peptides and peptidomimetics, enabling research and development in targeted therapeutic areas. This high-purity compound is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on drug discovery, proteomics, and biochemical studies.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in proteomics and enzymology studies to investigate enzyme-substrate interactions, particularly with proteases like dipeptidyl peptidase IV (DPP-IV).
• Peptidomimetic Development: Serves as a scaffold for designing and synthesizing peptidomimetics with enhanced metabolic stability and bioavailability.
• Academic & Contract Research: Employed in university and CRO laboratories for method development, teaching advanced peptide coupling techniques, and exploratory research.
• Custom Peptide Synthesis: A critical starting material for custom peptide synthesis services, enabling the production of specific peptide sequences for clients.

Basic Information

Product Name	Benzyloxycarbonylglycyl-L-Prolyl-L-Leucine
CAS No.	2646-63-1
Molecular Formula	C22H31N3O6
Molecular Weight	433.50 g/mol
Synonyms	Z-Gly-Pro-Leu-OH; Cbz-Gly-Pro-Leu-OH; N-Carbobenzoxy-glycyl-prolyl-leucine; Benzyl N-[(benzyloxy)carbonyl]glycyl-L-prolyl-L-leucinate; Z-Gly-Pro-Leu; Cbz-Gly-L-Pro-L-Leu-OH; Nα-Carbobenzoxy-glycyl-L-prolyl-L-leucine; Glycine, N-[(phenylmethoxy)carbonyl]-, L-prolyl-L-leucyl-
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonylglycyl-L-Prolyl-L-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.