Description

2-Fluoro-Dl-Phenylalanine is a fluorinated derivative of the essential amino acid phenylalanine, where a fluorine atom is substituted at the 2-position of the aromatic ring. This structural modification makes it a valuable non-natural amino acid building block for pharmaceutical research and the development of novel bioactive compounds. It is primarily utilized by research institutions and chemical manufacturers in the life sciences sector for applications in medicinal chemistry and peptide synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptide Synthesis: Used as a modified amino acid residue in solid-phase and solution-phase peptide synthesis to create fluorinated peptide analogs with altered stability, bioavailability, or receptor binding properties.
• Medicinal Chemistry & Drug Discovery: Employed in structure-activity relationship (SAR) studies to investigate the effects of fluorination on drug potency, selectivity, and metabolic profile.
• Biochemical Research: Acts as a tool compound in enzymatic studies, particularly to probe the activity of phenylalanine hydroxylase and related enzymes.
• Agrochemical Research: Investigated as a potential building block for novel herbicides or plant growth regulators that mimic amino acid activity.
• Positron Emission Tomography (PET) Tracer Development: The fluorine-18 radiolabeled analog is of significant interest for developing diagnostic imaging agents for neurological disorders.

Basic Information

Product Name	2-Fluoro-Dl-Phenylalanine
CAS No.	2629-55-2
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	DL-2-Fluorophenylalanine; (±)-2-Fluorophenylalanine; 2-Fluoro-DL-α-aminohydrocinnamic acid; (RS)-2-Amino-3-(2-fluorophenyl)propanoic acid; 2-F-Phe; 2-Fluoro-phenylalanine; α-Amino-2-fluorobenzenepropanoic acid; NSC 526257
EINECS	220-105-7

Quality Control

Our 2-Fluoro-Dl-Phenylalanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-Ratio ~50:50
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.