Description

4-Chloro-3,5-Difluoro-Phenylamine is a high-purity, halogenated aniline derivative serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides a versatile scaffold for constructing complex molecules with tailored properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, where the chloro and fluoro substituents enhance biological activity and stability.
• Material Science: Used in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Dye and Pigment Manufacturing: Intermediate for creating complex, light-fast dyes and functional pigments.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to form biaryl structures.
• Research & Development: A valuable compound for medicinal chemistry and process chemistry research in both academic and industrial settings.

Basic Information

Product Name	4-Chloro-3,5-Difluoro-Phenylamine
CAS No.	2613-33-4
Molecular Formula	C6H4ClF2N
Molecular Weight	163.55 g/mol
Synonyms	4-Chloro-3,5-difluoroaniline; 3,5-Difluoro-4-chloroaniline; 4-Chloro-3,5-difluorobenzenamine; 1-Amino-4-chloro-3,5-difluorobenzene; Benzenamine, 4-chloro-3,5-difluoro-; 4-Chloro-3,5-difluoro-phenylamine; 4-Chloro-3,5-difluoroaniline (principal synonym)
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluoro-Phenylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.