Description

2-Chloro-4,5-Difluoroaniline is a halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing difluorophenyl and chloroaniline motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the chloro and difluoro groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Dye and Pigment Manufacturing: Intermediate for synthesizing complex azo dyes and high-performance pigments.
• Liquid Crystal & OLED Materials: Building block for electronic chemicals used in display technologies.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for creating biaryl structures.

Basic Information

Product Name	2-Chloro-4,5-Difluoroaniline
CAS No.	2613-32-3
Molecular Formula	C6H4ClF2N
Molecular Weight	163.55 g/mol
Synonyms	2-Chloro-4,5-difluorobenzenamine; 4,5-Difluoro-2-chloroaniline; Benzenamine, 2-chloro-4,5-difluoro-; 2-Chloro-4,5-difluoro-phenylamine; 2613-32-3; 2-Chloro-4,5-difluoroaniline; 4,5-Difluoro-2-chlorobenzenamine
EINECS	220-046-3

Quality Control

Every batch of 2-Chloro-4,5-Difluoroaniline is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthesis applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.