Description

4-Chloro-2,5-Difluorophenylamine is a versatile halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine atoms on the aromatic ring, which allows for precise structural modifications and tuning of electronic properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro substituents contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating specialized aromatic amines used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed as a monomer or modifier in the production of high-performance polymers, such as polyimides and engineering plastics, to enhance thermal and chemical resistance.
• Dyestuff & Pigment Manufacturing: Acts as an intermediate for synthesizing complex azo dyes and high-value pigments, providing specific color fastness and hue properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for constructing complex biaryl and heterocyclic structures in medicinal chemistry.

Basic Information

Product Name	4-Chloro-2,5-Difluorophenylamine
CAS No.	2613-30-1
Molecular Formula	C6H4ClF2N
Molecular Weight	163.55 g/mol
Synonyms	2,5-Difluoro-4-chloroaniline; 4-Chloro-2,5-difluoroaniline; 1-Amino-4-chloro-2,5-difluorobenzene; Benzenamine, 4-chloro-2,5-difluoro-; 4-Chloro-2,5-difluorobenzenamine; 2,5-Difluoro-4-chlorobenzenamine; 4-Chloro-2,5-difluoro-phenylamine; 2613-30-1
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,5-Difluorophenylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent composition. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.