Description

Warfarin CAS NO 2610-86-8 is a potent synthetic anticoagulant belonging to the coumarin class of compounds. Its primary value lies in its ability to effectively inhibit vitamin K epoxide reductase, a critical enzyme in the synthesis of active blood clotting factors. This mechanism makes it an essential active pharmaceutical ingredient (API) for the formulation of anticoagulant medications. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for thromboembolic disorders, including deep vein thrombosis, pulmonary embolism, and for stroke prevention in patients with atrial fibrillation or prosthetic heart valves.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of oral anticoagulant tablets for human and veterinary medicine.
• Thrombosis Prevention: Used in medications to prevent and treat blood clots in conditions like deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Stroke and Systemic Embolism Prevention: Key component in drugs prescribed to reduce the risk of stroke in patients with non-valvular atrial fibrillation.
• Post-Surgical Prophylaxis: Employed in anticoagulant therapy following major surgeries, such as orthopedic joint replacements, to prevent clot formation.
• Veterinary Rodenticide: Historical and specialized use as a pest control agent, though this application is now highly regulated and separate from pharmaceutical grades.
• Biochemical Research: Used as a standard and tool compound in pharmacological and hematological studies focusing on coagulation pathways and vitamin K metabolism.

Basic Information

Product Name	Warfarin
CAS No.	2610-86-8
Molecular Formula	C19H16O4
Molecular Weight	308.33 g/mol
Synonyms	4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; 3-(α-Acetonylbenzyl)-4-hydroxycoumarin; WARF-42; Coumadin® (brand name); Marevan® (brand name); Jantoven® (brand name); Athrombin-K; Panawarfin
EINECS	220-024-6

Quality Control

Our Warfarin is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Quality is verified through comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. We can supply material compliant with various pharmacopeial standards, including USP and EP monographs. A detailed Certificate of Analysis (COA) is provided with each batch to guarantee purity, identity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture absorption.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.