Description

γ-Methyl-L-Glutamic Acid is a non-proteinogenic amino acid derivative of L-glutamic acid, featuring a methyl group substitution on the gamma carbon. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is particularly sought after by manufacturers and R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in neurological and metabolic disorder research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified glutamic acid residues, influencing peptide stability and bioactivity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Agrochemical Development: Employed as a precursor in the synthesis of novel herbicides, pesticides, and plant growth regulators with enhanced selectivity.
• Ligand and Catalyst Design: Utilized in the creation of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Food & Flavor Science: Investigated for its potential role as a precursor to novel umami flavor enhancers or taste modulators.

Basic Information

Product Name	γ-Methyl-L-Glutamic Acid
CAS No.	2596-04-5
Molecular Formula	C6H11NO4
Molecular Weight	161.16 g/mol
Synonyms	(2S)-2-Amino-4-methoxy-4-oxobutanoic acid; L-γ-Methylglutamate; (S)-2-Amino-4-methoxy-4-oxobutanoic acid; γ-Methoxy-L-glutamic acid; Methyl L-glutamate derivative; 4-Methoxy-L-glutamic acid; γ-Methyl L-glutamate
EINECS	219-998-7

Quality Control

Every batch of γ-Methyl-L-Glutamic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation to ensure product integrity and traceability for our global B2B clients. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available for each lot. Our standard grade meets typical research and industrial specifications, with options for higher purity grades (e.g., >98%, >99%) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% L-isomer
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.