Description

Boc-L-Threonine is a protected derivative of the essential amino acid L-Threonine, featuring a tert-butoxycarbonyl (Boc) group. This protection is critical for enabling selective peptide bond formation in complex organic syntheses, particularly in solid-phase peptide synthesis (SPPS). It is an indispensable building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research biochemicals.

Application

• Peptide Synthesis: A fundamental amino acid derivative for the stepwise construction of custom peptides in both research and GMP manufacturing environments.
• Pharmaceutical Intermediates: Serves as a key chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation & Linker Chemistry: Used in the preparation of peptide-protein conjugates, antibody-drug conjugates (ADCs), and other bioconjugates.
• Biochemical Research: Employed in studying enzyme mechanisms, protein structure-function relationships, and metabolic pathways.
• Combinatorial Chemistry: Utilized in the generation of diverse chemical libraries for high-throughput screening in drug discovery.
• Protecting Group Strategy: The Boc group is used to temporarily mask the amino functionality, allowing for orthogonal deprotection in multi-step syntheses.

Basic Information

Product Name	Boc-L-Threonine
CAS No.	2592-18-9
Molecular Formula	C9H17NO5
Molecular Weight	219.24 g/mol
Synonyms	(2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxybutanoic acid; N-(tert-Butoxycarbonyl)-L-threonine; N-Boc-L-threonine; Boc-Thr-OH; BOC-THR; tert-Butyloxycarbonyl-L-threonine; (2S,3R)-3-Hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid; L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	219-989-2

Quality Control

Our Boc-L-Threonine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specific results for assay, optical rotation, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]20/D	-30.0° to -34.0° (c=1 in AcOH)
Specific Optical Rotation	-30.0° to -34.0°
Loss on Drying	≤0.5%
Heavy Metals (as Pb)	≤10 ppm
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.