Description

H-Phe-Phe-Phe-Oh is a synthetic tripeptide composed of three L-phenylalanine residues with a free C-terminal carboxylic acid. This compound serves as a crucial building block and model substrate in biochemical and pharmaceutical research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers for applications in peptide synthesis, enzyme studies, and drug discovery.

Application

• Pharmaceutical Research & Development: As a model peptide substrate for studying enzyme kinetics, particularly for proteases like chymotrypsin or pepsin.
• Peptide Synthesis: Serving as a key intermediate or a protected fragment in the solid-phase or solution-phase synthesis of longer, more complex peptide chains.
• Biochemical Studies: Investigating protein-protein interactions, aggregation phenomena (e.g., amyloid formation), and structural biology due to its aromatic side chains.
• Standards & Calibration: Used as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for method development and quality control.
• Academic Research: Fundamental studies in organic chemistry, peptide chemistry, and medicinal chemistry for exploring structure-activity relationships (SAR).

Basic Information

Product Name	H-Phe-Phe-Phe-Oh
CAS No.	2578-81-6
Molecular Formula	C30H33N3O5
Molecular Weight	515.60 g/mol
Synonyms	L-Phenylalanyl-L-phenylalanyl-L-phenylalanine; FFF; Phe-Phe-Phe; Tri-L-phenylalanine; H-Phe-Phe-Phe-OH; N-(N-L-Phenylalanyl-L-phenylalanyl)-L-phenylalanine; (S)-2-((S)-2-((S)-2-Amino-3-phenylpropanamido)-3-phenylpropanamido)-3-phenylpropanoic acid
EINECS	Contact for details

Quality Control

Our H-Phe-Phe-Phe-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency. We provide Certificates of Analysis (COA) detailing purity, identity, and impurity profiles via methods such as HPLC, NMR, and MS. Specifications can be tailored to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.