Description

H-His-Gly-Oh CAS NO 2578-58-7 is a high-purity dipeptide derivative, specifically the C-terminal carboxylic acid form of the histidylglycine sequence. This compound is a critical building block in peptide synthesis and biochemical research, valued for its role in constructing more complex peptide structures. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research laboratories focused on peptide-based drug discovery, enzyme substrate studies, and proteomics.

Application

• Pharmaceutical Intermediates: Serves as a key raw material and protected fragment in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a standard, substrate, or inhibitor in enzymatic studies, particularly those involving histidine-containing active sites.
• Protease & Enzyme Substrates: Employed in the development and testing of assays for proteolytic enzymes like dipeptidyl peptidases.
• Nutritional Science: Investigated for its potential role as a metabolic intermediate or bioactive peptide precursor in nutritional studies.
• Cosmetic Peptide Synthesis: Acts as a component in the manufacture of certain bioactive peptides for cosmetic applications targeting skin health.

Basic Information

Product Name	H-His-Gly-Oh
CAS No.	2578-58-7
Molecular Formula	C8H12N4O3
Molecular Weight	212.21 g/mol
Synonyms	Histidylglycine; L-Histidyl-glycine; Glycine, L-histidyl-; H-His-Gly; Histidine-Glycine dipeptide; L-Histidylglycine; N-(2-Amino-2-oxoethyl)-L-histidine; (2S)-2-[[(2S)-2-Amino-1-hydroxy-3-(1H-imidazol-4-yl)propylidene]amino]acetic acid
EINECS	219-936-3

Quality Control

Our H-His-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, chiral analysis for enantiomeric purity, and identity confirmation via mass spectrometry and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	-20° to -25° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.