Description

H-D-Glu(Obzl)-Oh CAS NO 2578-33-8 is a protected glutamic acid derivative, specifically the benzyl ester of D-glutamic acid, serving as a crucial chiral building block in organic synthesis. This compound is essential for researchers and manufacturers requiring high-purity, enantiomerically pure intermediates to ensure the stereochemical integrity of final products. It is primarily utilized in the development of pharmaceuticals, bioactive peptides, and complex organic molecules where precise chirality is non-negotiable.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-glutamic acid residues with a protected side chain.
• Bioconjugation & Probe Development: Acts as a linker or spacer molecule in the creation of bioconjugates, fluorescent probes, and diagnostic agents.
• Chemical Biology Research: Employed in studying enzyme mechanisms, receptor-ligand interactions, and metabolic pathways using isotopically labeled versions.
• Asymmetric Synthesis Catalyst Precursor: Serves as a precursor for chiral ligands or catalysts used in asymmetric transformations.
• Custom Synthesis & Process Development: A vital starting material for contract research and manufacturing organizations (CROs/CMOs) developing custom synthetic routes.

Basic Information

Product Name	H-D-Glu(Obzl)-Oh
CAS No.	2578-33-8
Molecular Formula	C₁₂H₁₅NO₄
Molecular Weight	237.25 g/mol
Synonyms	D-Glutamic acid 5-benzyl ester; (R)-2-Amino-5-(benzyloxy)-5-oxopentanoic acid; H-D-Glu(OBzl)-OH; D-Glu(OBzl)-OH; Benzyl D-glutamate; D-2-Aminoglutaric acid 5-benzyl ester; D-Glutamic acid γ-benzyl ester; Boc-D-Glu(OBzl)-OH precursor
EINECS	Contact for details

Quality Control

Our H-D-Glu(Obzl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Specific Rotation	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.