Description

Methyl L-Isoleucinate CAS NO 2577-46-0 is a high-purity, protected amino acid derivative essential for advanced organic synthesis and peptide research. This compound serves as a critical chiral building block, enabling the controlled introduction of the L-isoleucine moiety into complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams, peptide chemists, and fine chemical manufacturers for developing novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of peptide-based drugs, enzyme inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid ester to construct specific peptide sequences.
• Biochemical Research: Employed as a standard or reagent in metabolic studies, protein engineering, and structure-activity relationship (SAR) investigations.
• Fine Chemical Production: Acts as a precursor for custom catalysts, chiral ligands, and other specialty chemicals requiring high enantiomeric purity.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing complex flavoring agents and aroma compounds.
• Academic & Industrial R&D: Serves as a valuable tool for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Item	Details
Product Name	Methyl L-Isoleucinate
CAS No.	2577-46-0
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	L-Isoleucine methyl ester; Methyl (2S,3S)-2-amino-3-methylpentanoate; (2S,3S)-2-Amino-3-methylpentanoic acid methyl ester; H-Ile-OMe; Isoleucine methyl ester; L-Ile-OMe; Methyl L-2-amino-3-methylvalerate; Methyl ester of L-isoleucine
EINECS	219-935-5

Quality Control

Our Methyl L-Isoleucinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Specific Rotation [α]	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.