Description

Ibotenic Acid CAS NO 2552-55-8 is a potent neuroactive isoxazole derivative, structurally related to the neurotransmitter glutamic acid. This compound is of significant interest in neuroscience and pharmacological research due to its action as a potent agonist at glutamate receptors. It serves as a critical biochemical tool for studying excitatory neurotransmission, neuronal excitotoxicity, and neurodegenerative pathways. Key industries that require this high-purity reference standard include pharmaceutical R&D, academic research institutions, and biotechnology companies focused on neurology.

Application

• Neuroscience Research: Primary tool for studying the function and pharmacology of ionotropic glutamate receptors (iGluRs), particularly the NMDA and AMPA/kainate receptor subtypes.
• Neurotoxicity Models: Used to induce selective neuronal lesions in animal models to study neurodegenerative diseases, such as Alzheimer's and Huntington's disease, and to map neural pathways.
• Pharmacological Standard: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development and testing of novel neuroprotective agents or glutamate receptor modulators.
• Biochemical Studies: Employed in receptor binding assays and functional studies to characterize new compounds targeting the glutamatergic system.
• Toxicology Research: Used in studies investigating excitotoxicity and mechanisms of cell death following stroke or brain injury.

Basic Information

Product Name	Ibotenic Acid
CAS No.	2552-55-8
Molecular Formula	C5H6N2O4
Molecular Weight	158.11 g/mol
Synonyms	(S)-2-Amino-2-(3-hydroxyisoxazol-5-yl)acetic acid; (S)-Ibotenic acid; Ibotenate; α-Amino-3-hydroxy-5-isoxazoleacetic acid; 5-Isoxazolol, 3-hydroxy-, α-amino-, (αS)-; Amantin (neurotoxin); O-Amino-3-hydroxy-5-isoxazoleacetic acid
EINECS	219-852-7

Quality Control

Our Ibotenic Acid is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for reference materials, and our quality control protocols include rigorous analytical testing to meet the exacting requirements of the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.