Description

Physalaemin CAS NO 2507-24-6 is a bioactive undecapeptide originally isolated from the skin of the *Physalaemus* genus of frogs. This compound is of significant interest in biochemical and pharmacological research due to its potent vasodilatory and smooth muscle-stimulating properties. It serves as a critical reference standard and research tool for neuroscientists and pharmacologists studying neurokinin receptors, peptide signaling pathways, and inflammatory responses.

Application

• Neuroscience Research: Used as a potent agonist for neurokinin receptors (NK1, NK2) to study pain transmission, neurogenic inflammation, and central nervous system functions.
• Pharmacological Studies: Employed in vitro and in vivo to investigate smooth muscle contraction, vasodilation, and bronchoconstriction mechanisms.
• Biochemical Reference Standard: Serves as a high-purity calibrant in analytical methods such as HPLC and mass spectrometry for peptide quantification and identification.
• Drug Discovery & Development: Acts as a lead compound or tool molecule for screening and developing novel therapeutics targeting tachykinin pathways.
• Academic & Institutional Research: Essential for universities and research institutes conducting fundamental studies on peptide biology and receptor-ligand interactions.

Basic Information

Product Name	Physalaemin
CAS No.	2507-24-6
Molecular Formula	C58H83N13O15S
Molecular Weight	1210.4 g/mol
Synonyms	Physalaemin; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; Physalaemin (frog); Tachykinin peptide; Neurokinin agonist; Undecapeptide Physalaemin
EINECS	Contact for details

Quality Control

Our Physalaemin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature and propensity to be easily oxidized (store under inert atmosphere), the product should be kept under dry, inert conditions (e.g., under argon or nitrogen) and allowed to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.