Description

n-Acetyl-L-Histidine is a modified amino acid derivative where an acetyl group is attached to the L-histidine molecule. This modification enhances its stability and alters its biochemical properties, making it a valuable intermediate for advanced research and synthesis. It is primarily utilized in the pharmaceutical and life science sectors for applications ranging from biochemical research to the development of novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a key reagent or substrate in enzymatic studies, metabolic pathway analysis, and proteomics research.
• Cosmetic & Skincare Formulations: Investigated for potential use in anti-aging and skin-conditioning products due to its peptide-like structure.
• Nutritional Science: Studied as a potential precursor or metabolite in advanced nutritional and dietary supplement research.
• Diagnostic Agent Development: Employed in the development of biochemical assays and diagnostic markers.
• Peptide Synthesis: Acts as a protected building block in solid-phase and solution-phase peptide synthesis.

Basic Information

Product Name	n-Acetyl-L-Histidine
CAS No.	2497-02-1
Molecular Formula	C8H11N3O3
Molecular Weight	197.19 g/mol
Synonyms	N-α-Acetyl-L-histidine; N-Acetylhistidine; L-Histidine, N-acetyl-; Ac-His-OH; (2S)-2-Acetamido-3-(1H-imidazol-4-yl)propanoic acid; NSC 163063; N-Acetyl-L-histidine, free acid
EINECS	219-694-9

Quality Control

Our n-Acetyl-L-Histidine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-20.0° to -25.0° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.