Description

H-(2S,4R)-γ-Hydroxy-Glu-Oh is a high-purity, stereochemically defined derivative of glutamic acid, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its unique γ-hydroxy substitution pattern makes it a valuable scaffold for constructing complex molecules with specific biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in peptide and peptidomimetic drug discovery.
• Peptide Synthesis: Used as a protected or unprotected amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce specific structural motifs.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard for analytical method development in life science research.
• Fine Chemical Production: Employed in the synthesis of complex natural products, specialty chemicals, and advanced materials requiring precise stereochemical control.
• Prodrug Development: Utilized in designing prodrugs where the γ-hydroxy group can be functionalized to modify solubility, bioavailability, or targeting properties.

Basic Information

Item	Details
Product Name	H-(2S,4R)-γ-Hydroxy-Glu-Oh
CAS No.	2485-33-8
Molecular Formula	C5H9NO5
Molecular Weight	163.13 g/mol
Synonyms	(2S,4R)-4-Hydroxyglutamic Acid; (2S,4R)-Hygric Acid; L-erythro-4-Hydroxyglutamic Acid; γ-Hydroxy-L-glutamic Acid; (2S,4R)-4-Hydroxy-DL-glutamic Acid; H-Glu(4-OH)-OH; 4-Hydroxy-L-glutamate
EINECS	Contact for details

Quality Control

Our H-(2S,4R)-γ-Hydroxy-Glu-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (by HPLC), chiral purity, residual solvents, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (for specified isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.