Description

D-S-tert-Butylcysteine is a high-purity, non-proteinogenic amino acid derivative featuring a tert-butyl-protected thiol group. This compound is a critical chiral building block and protecting group reagent in advanced organic synthesis and pharmaceutical research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-fidelity intermediates for peptide synthesis, drug discovery, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug molecules, particularly those targeting cysteine proteases or requiring thiol protection.
• Peptide Synthesis: Used as a protected cysteine derivative in Solid-Phase Peptide Synthesis (SPPS) to prevent unwanted disulfide bond formation during assembly.
• Bioconjugation & Protein Engineering: Acts as a handle for site-specific modification of proteins and antibodies via its protected thiol, which can be deprotected for selective coupling.
• Protecting Group Reagent: The tert-butylthio (S-t-Bu) group is employed to protect cysteine residues in multi-step synthetic sequences, offering stability under various reaction conditions.
• Research & Development: Utilized in academic and industrial R&D for studying enzyme mechanisms, protein folding, and developing new synthetic methodologies.
• Ligand Synthesis: A precursor for creating chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	D-S-tert-Butylcysteine
CAS No.	2481-10-9
Molecular Formula	C7H15NO2S
Molecular Weight	177.26 g/mol
Synonyms	D-Cysteine, S-tert-butyl derivative; (R)-2-Amino-3-(tert-butylthio)propanoic acid; D-3-(tert-Butylthio)alanine; D-S-tert-Butylcysteine; D-Cysteine(S-t-butyl); (R)-S-tert-Butylcysteine; tert-Butyl D-cysteinate; D-2-Amino-3-(tert-butylthio)propionic acid
EINECS	219-623-9

Quality Control

Our D-S-tert-Butylcysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.